Day 1 :
Keynote Forum
Gabriel Demetrio Dimitrov
University of Milan, Italy
Keynote: Arterial stiffness and subendocardial viability ratio in patients with peripheral artery disease
Time : 10:00-10:40
Biography:
Gabriel Demetrio Dimitrov born in New York 1963. Gabriel Demetrio graduated from the University of Pavia, Italy Medical School (1991), and Specialised in Vascular Medicine from the University of Pavia, Italy with USMLE certificate in 1996. Gabriel Demetrio currently working as a clinical physician department of Angiology in L.Sacco Hospital-Research Center on Vascular Diseases - University of Milan.Gabriel Demetrio is also a VAS-Vascular Independent Researcher and Education European Organization, Co-author of chapter on Arterial Stiffness in VAS European Book on Angiology - Vascular Medicine 2018. Also he is co-author and presenter abstracts at many conferences in USA, European Symposiums, co-author of many articles in international journals. He has particular research interests in arterial stiffness, peripheral arterial disease. Member US Society of Vascular Medicine Taskforce on Vascular Medicine Practice.
Abstract:
Arterial stiffening is a hallmark of the aging process and atherosclerosis, including peripheral arterial disease (PAD). We investigated the associations between carotid-femoral pulse wave velocity (c-fPWV), augmentation index corrected for heart rate (Aix@HR75), ankle-brachial index (ABI), and subendocardial viability ratio (SEVR), an indicator of cardiac perfusion. The c-fPWV, Aix@HR75, and SEVR was estimated using applanation tonometry. The ankle systolic pressure measurements for the calculation of the ABI were obtained using an 8-mHz Doppler probe. The study group included 555 subjects, mean age 63±11 years (248 PAD (ABI <1.0) and 307 non-PAD (ABI ≥1.0 ≤1.3). After the stepwise selection process PAD and non-PAD patients SEVR was not related to c-fPWV and ABI (P= .154; P= .156) and (P= .101; P= .402), respectively. In PAD patients, SEVR was negatively related to Aix@HR75 (P< .0001) and aortic PP (P= .0005) In conclusion, arterial stiffness is associated with non invasive indices of myocardial perfusion in PAD patients, suggesting a potential pathophysiological link for increased cardiovascular events.
Keynote Forum
Yong Dai
Jinan University, China
Keynote: Diversity and clonality of B-cell and T-cell receptors in IgA nephropathy
Time : 10:40-11:20
Biography:
Yong Dai has completed his MD at Sun Yat-sen University Zhongshan School of Medicine and postdoctoral studies from Nephrology department of Erlangen- Nuremberg university in Germany. He is the chief physician of nephrology and the director of Clinical Medical Research Center of Second Clinical Medical College, Jinan University. Also he is deputy director of Kidney Research Institute of Jinan University. He has published more than 140 SCI articles in reputed journals
Abstract:
Immunoglobulin A nephropathy (IgAN) is the most common cause of glomerular hematuria and one of the leading causes of end-stage renal disease (ESRD). Immune dysregulation contributes to this fatal disorder. Therefore, the receptor of the immune cells (mainly B/T Cells) may be valuable for the development of specific immunotherapeutic interventions. We isolated B cells and T cells from peripheral blood of IgAN patients and healthy controls and analyzed the composition of the BCR/TCR CDR3 by multiplex PCR, high-throughput sequencing and bioinformatics. The results revealed that the BCR/TCR CDR3 clones were expressed at very low frequencies, and the composition of clone types in IgAN patients was skewed; vast majority of clones were unique. Only 12 BCR and 228 TCR CDR3 clones were public clones, of which 16 public clones were expressed at a significantly higher frequency in IgAN patients (P<0.001). There were also specific conserved amino acid residues between these unique clones or groups, and the residues GMDV, EQY and EQF were recurring only in the IgAN group. Besides, some VDJ gene recombinations showed considerable variation between groups, including 4 high-frequency VDJ gene recombinations in the IgAN patients (P<0.001). Immune repertoires provide tremendous novel information, and conserved BCR/TCR CDR3 clones and VDJ gene recombinations with great variation may be potential therapeutic targets for IgAN patients.