Nikolai A Bazaev
National Research University of Electronic Technology, Russia
Title: Concepts of wearable artificial kidney development
Biography
Biography: Nikolai A Bazaev
Abstract
The work is devoted to results of dialysis regeneration methods investigation. The aim of the work is to construct a wearable artificial kidney that carries out prolonged continuous peritoneal dialysis. The dialysis fluid is recirculated through an extracorporeal circuit, which undergoes regeneration. Several activated carbons and hemosorbents were evaluated as potential sorpiton material. Three methods of urea elimination were aprobated: Immobilized urease, electrooxidation and thermal degradation. As a result, a prototype of a wearable artificial kidney was assembled. Its regeneration unit is based on electrolysis and gives opportunity to reach the urea elimination rate up to 1.2 g/h; creatine and uric acid elimination rates both equals to 0.3 mg/h (in vitro experinents). Along with that it is possible to keep concentration of sodium, chlorine and calcium ions in the range of 10% deviation from the starting value. The prototype of WAK is designed as a backpack and weights about 3.5 kg. In vivo experiment showed that the prototype carries out its functions, gives opportunity to eliminate exeeded fluid from peritoneal cavity and doesn’t affect blood pH during dialysis.