Surapon Nochaiwong
Chiang Mai University, Thailand
Title: Development of a multidimensional assessment tool for uremic pruritus in dialysis patients (up-dial)
Biography
Biography: Surapon Nochaiwong
Abstract
Dialysis patients with uremic pruritus (UP) have a significantly higher risk of mortality and a poor quality of life. This study aimed to develop and validate a multidimensional scale assessing the UP: Uremic Pruritus in Dialysis Patients (UP-Dial). The development and validation of the UP-Dial instrument was conducted in four phases: (1) Item generation, (2) development of pilot questionnaire, (3) refinement with patient recruitment, and (4) psychometric validation. Participants completed the UP-Dial, the visual analogue scale (VAS) of UP, the Dermatology Life Quality Index (DLQI), the Kidney Disease Quality of Life-36 (KDQOL-36), the Pittsburgh Sleep Quality Index (PSQI), and the Beck Depression Inventory (BDI) during May 15, 2012 to November 30, 2015. The 27-item pilot UP-Dial was generated with 168 participants. After factor analyses, the final 14-item UP-Dial encompassed three domains: Signs and symptoms, psychosocial, and sleep. Face and content validity were satisfied through the item generation process and review of experts. The psychometric analysis demonstrated that the UP-Dial had good convergent and discriminant validity. The UP-Dial was significantly correlated (Spearman rank correlation, [95% CI]) with the VAS-UP (0.76 [0.69 to 0.83]), DLQI (0.78 [0.71 to 0.85]), KDQOL-36 (-0.86 [-0.91 to -0.81]), PSQI (0.85 [0.80 to 0.89]), and BDI (0.70 [0.61 to 0.79]). The UP-Dial revealed excellent internal consistency (Cronbach’s α 0.90 [0.87 to 0.92]) and reproducibility (intraclass correlation 0.95 [0.90 to 0.98]). The UP-Dial is valid and reliable for assessing UP among dialysis patients. This questionnaire can be used to standardize the effects of intervention in comparative-effectiveness research.