Saad Djaballah Djihad
University hospital of Blida, Algeria
Title: Management of renal involvement in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome): A case report
Biography
Biography: Saad Djaballah Djihad
Abstract
Introduction:
Eosinophilic granulomatosis with polyangiitis is a rare systemic vasculitis, Characterized by an eosinophilic tissue infiltrate. Rapidly progressive glomerulonephritis is a severe complication of Churg- Strauss syndrome (CSS). The objective of our observation is to show the efficiency of early treatment of renal involvement in eosinophilic granulomatosis with polyangiitis (Churg- Strauss syndrome).
Patients and methods:
We report the case of a 59-year-old man with eosinophilic granulomatosis with polyangiitis (CSS), who was admitted to our department of nephrology for the management of rapidly progressive glomerulonephritis. He was clinically diagnosed to have CSS based on remarkable eosinophila, history of asthma, peripheral neuropathy, pulmonary infiltrates and rapidly progressive glomerulonephritis. The anti-neutrophil cytoplasmic antibodies (pANCA) were positive. The renal biopsy found extra-capillary glomerulonephritis. As induction therapy intravenous cyclophosphamide was used in addition to corticosteroids and plasma exchanges followed by maintenance therapy using azathioprine and steroids.
Results:
The treatment of renal involvement in Churg and Strauss syndrome is currently based on the realization of plasma exchanges associated with corticosteroid therapy and immunosuppression. In this case the evolution was favorable with a renal and neurogical remission and reduction of ANCA rate. 6 months later still no relapse and the tolerance of the treatment is good, no infectious or neoplastic complications are observed up until today.
Conclusion:
The early diagnosis and treatment may lead to favorable outcomes in eosinophilic granulomatosis with polyangiitis complicated by rapidly progressive glomerulonephritis.