20^th Global Nephrologists Annual Meeting

Biography

Biography: Nevra Alkanli

Abstract

microRNAs (miRNAs) are short-noncoding RNAs that play an important role in the regulation of pathophysiological processes that suppress gene expression. They perform their functions by binding to messenger RNAs. These biomolecules play an important role in gene regulation and protein expression. miRNAs are important for better understanding of kidney pathologies. miRNAs have been associated with various renal diseases, such as particularly renal cell carcinoma, diabetic nephropathy, nephritic syndrome, kidney fibrosis, lupus nephritis, acute pyelonephritis. One of these diseases, diabetic nephropathy, is a progressive kidney disease and can lead to end-stage renal disease due to diabetes-related complications. Diabetic nephropathy is known to be associated with accumulation of extracellular matrix proteins, glomerular basement membrane thickening, mesangial expansion, and hypertrophy. There are also studies showing that miRNAs are important in the development of diabetic nephropathy. miRNAs associated with diabetic nephropathy have been shown to be effective in controlling the expression of Transforming Growth Factor-Beta. Transforming Growth Factor-Beta mediated miRNA regulation plays an important role in the development of diabetic nephropathy. Transforming Growth Factor-Beta, known to be associated with chronic kidney disease, is also known to be effective in the development of glomerular cell proliferation and glomerular HCM. miRNAs and Transforming Growth Factor-Beta together regulate  mitochondrial dysfunction, oxidative stress, and energy metabolism in renal damage due to oxidative stress. The purpose of this study is to examinate the relationship between Transformative Growth Factor-Beta-related miRNAs and development of diabetic nephropathy. Determining this relationship in diabetic nephropathy will help to develop new treatment methods and drugs.