Trakya University, Turkey
Title: Renalase gene variations and serum trace elements related in oxidative stress in chronic renal failure or End Stage Renal Disease
Biography: Arzu Ay
Renalase is one of the enzymes that play an important role in kidney function. This flavoprotein enzyme functions by participating in the metabolism of circulating catecholamines. Renalase plays an important role in the regulation of blood pressure. Increased blood pressure occurs in the case of renalase enzyme deficiency. In renal diseases such as Chronic Renal Failure (CRF) and End Stage Renal Disease (ESRD), renalase enzyme levels decrease and hypertension develops. The human renalase encoding gene (RNLS) consists of 10 exons and is localized on chromosome 10 (q23.33). Many single nucleotide gene polymorphisms (SNPs) have been identified in the highly polymorphic RNLS gene. Renalase SNPs occurs as a result of a reduction in renalase gene expression. This decrease is thought to be associated with an increase in blood pressure. Therefore, genetic variations in the renalase gene may be associated with hypertension. CRF or ESRD occurs as a result of permanent severe damage in kidney function. In these diseases, the function of removing normal kidney toxic molecules from the body is lost. CRF or ESRD is often associated with oxidative stress, antioxidant depletion, imbalances in some trace elements such as copper, zinc and selenium concentrations in the body. Serum concentrations of trace elements are also affected by factors such as renal breakthrough insufficiency, degree of renal failure and metabolic changes associated with renal failure. The purpose of this study is to examine the role of renalase gene variations in CRF or ESRD disease and the trace elements associated with oxidative stress.